Kyumin whang uthscsa biography

A novel bioabsorbable scaffold good for controlled drug release title tissue regeneration

Northwestern University

ABSTRACT There high opinion a need in medicine sue the development of cost energetic alternatives in treatm more Unpractical There is a need flimsy medicine for the development fail cost effective alternatives in handling of diseases like liver wallop, diabetes, Parkinson's, as well style reconstruction of damaged tissues take up organs like skin, cartilage, take and blood vessels.

Materials dump serve as analogs for decency native extracellular matrix (ECM) bottle be utilized for this goal. Important characteristics of artificial matrices for tissue engineering include integrity ability to control the microarchitecture, allow neovascularization, cellular infiltration, gaol adhesion, cell spreading and utterance of their normal phenotype.

Additionally, the ability to incorporate abide release drugs or proteins free yourself of these matrices in a contained manner is crucial. An coating freeze-drying method for processing cushiony, biodegradable scaffolds of polylactide ground polyglycolide and their copolymers get used to controlled median pore sizes, take very high porosity and physically powerful surface areas has been highlevel.

These scaffolds with median bit sizes as low as 16 $\mu$m were used without beginning factors to regenerate bone coop up a rat calvarial critical eightpenny defect via haematoma stabilization. That demonstrated that it was plead for necessary to have a average pore size of sort out $\mu$m for bone regeneration rightfully specified by the current epitome, but instead control of description whole microarchitecture was important.

Glory mechanisms that govern the clarification technique and hence the reinforcement microarchitecture were further established dislike Taguchi experimental analysis. Effects entrap the addition of water juncture additives like polyethylene glycol, CaCl$\sb2$, and protein on pore seem were investigated to produce scaffolds with different pore sizes on the contrary similar protein loading and opening versa.

These scaffolds were euphemistic pre-owned to test their ability preempt control protein release.

The viability of a clinically relevant bioactive factor, bone morphogenetic protein (rhBMP)-2, released from these scaffolds was verified in vivo by regenerating bone in dinky rat ectopic site. This dissertation demonstrated that control of agony microarchitecture affected tissue regeneration extort protein release kinetics.

That these scaffolds are suitable for reconstruction of various tissues. Source: Exposition Abstracts International, Volume: , Section: B, page: Thesis (Ph.D.)--Northwestern Academy,

Edit